PSMA4 Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Belongs to the peptidase T1A family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.25.1; Protease; Proteasome complex
Chromosomal Location of mouse Ortholog: 9|9 B
Cellular Component:  cytoplasm; cytosol; intracellular membrane-bounded organelle; nucleoplasm; nucleus; P-body; proteasome complex; proteasome core complex; proteasome core complex, alpha-subunit complex
Biological Process:  proteasomal protein catabolic process; proteolysis involved in protein catabolic process; ubiquitin-dependent protein catabolic process
Reference #:  Q9R1P0 (UniProtKB)
Alt. Names/Synonyms: C9; Macropain subunit C9; Multicatalytic endopeptidase complex subunit C9; proteasome (prosome, macropain) subunit, alpha type 4; Proteasome component C9; proteasome subunit alpha 4; Proteasome subunit alpha type-4; Proteasome subunit L; PSA4; Psma4
Gene Symbols: Psma4
Molecular weight: 29,471 Da
Basal Isoelectric point: 7.58  Predict pI for various phosphorylation states
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PSMA4

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein