caveolin-1 May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation. Belongs to the caveolin family. Skeletal muscle, liver, stomach, lung, kidney and heart (at protein level). Expressed in the brain. 2 alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 7q31.2
Cellular Component:  acrosomal membrane; caveola; cell cortex; cilium; cytoplasmic vesicle; early endosome membrane; endocytic vesicle membrane; endoplasmic reticulum; endoplasmic reticulum membrane; endosome; Golgi membrane; lipid droplet; membrane; membrane raft; perinuclear region of cytoplasm; plasma membrane; protein-containing complex
Molecular Function:  ATPase binding; cholesterol binding; enzyme binding; identical protein binding; inward rectifier potassium channel inhibitor activity; ion channel binding; molecular adaptor activity; nitric-oxide synthase binding; patched binding; peptidase activator activity; protein binding; protein binding, bridging; protein heterodimerization activity; protein kinase binding; Rac GTPase binding; signaling receptor binding
Biological Process:  angiogenesis; angiotensin-activated signaling pathway involved in heart process; apoptotic signaling pathway; beta-catenin destruction complex disassembly; calcium ion homeostasis; calcium ion transport; caveola assembly; caveolin-mediated endocytosis; cellular calcium ion homeostasis; cellular response to exogenous dsRNA; cellular response to hyperoxia; cellular response to peptide hormone stimulus; cellular response to transforming growth factor beta stimulus; cholesterol homeostasis; cholesterol transport; inactivation of MAPK activity; lactation; leukocyte migration; lipid storage; maintenance of protein location in cell; mammary gland development; mammary gland involution; membrane depolarization; negative regulation of anoikis; negative regulation of canonical Wnt signaling pathway; negative regulation of cytokine-mediated signaling pathway; negative regulation of endothelial cell proliferation; negative regulation of epithelial cell differentiation; negative regulation of inward rectifier potassium channel activity; negative regulation of JAK-STAT cascade; negative regulation of MAPK cascade; negative regulation of necroptotic process; negative regulation of nitric oxide biosynthetic process; negative regulation of nitric-oxide synthase activity; negative regulation of peptidyl-serine phosphorylation; negative regulation of peptidyl-tyrosine autophosphorylation; negative regulation of pinocytosis; negative regulation of potassium ion transmembrane transport; negative regulation of protein binding; negative regulation of protein tyrosine kinase activity; negative regulation of protein ubiquitination; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of tyrosine phosphorylation of STAT protein; nitric oxide homeostasis; positive regulation of calcium ion transport into cytosol; positive regulation of canonical Wnt signaling pathway; positive regulation of catalytic activity; positive regulation of cell adhesion molecule production; positive regulation of cell migration; positive regulation of cold-induced thermogenesis; positive regulation of ER-associated ubiquitin-dependent protein catabolic process; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of gap junction assembly; positive regulation of gene expression; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of NF-kappaB transcription factor activity; positive regulation of peptidase activity; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein binding; positive regulation of protein ubiquitination; positive regulation of toll-like receptor 3 signaling pathway; positive regulation of vasoconstriction; posttranscriptional regulation of gene expression; protein homooligomerization; protein localization; protein localization to basolateral plasma membrane; protein localization to plasma membrane raft; receptor internalization; receptor internalization involved in canonical Wnt signaling pathway; receptor-mediated endocytosis of virus by host cell; regulation of blood coagulation; regulation of cardiac muscle cell action potential involved in regulation of contraction; regulation of cell communication by electrical coupling involved in cardiac conduction; regulation of cytosolic calcium ion concentration; regulation of entry of bacterium into host cell; regulation of fatty acid metabolic process; regulation of heart rate by cardiac conduction; regulation of membrane repolarization during action potential; regulation of nitric-oxide synthase activity; regulation of peptidase activity; regulation of ruffle assembly; regulation of smooth muscle contraction; regulation of the force of heart contraction by chemical signal; regulation of ventricular cardiac muscle cell action potential; response to bacterium; response to calcium ion; response to estrogen; response to hypoxia; response to ischemia; response to progesterone; skeletal muscle tissue development; T cell costimulation; triglyceride metabolic process; vasculogenesis; vasoconstriction; vesicle organization
Disease: Lipodystrophy, Congenital Generalized, Type 3; Partial Lipodystrophy, Congenital Cataracts, And Neurodegeneration Syndrome; Pulmonary Hypertension, Primary, 3
Reference #:  Q03135 (UniProtKB)
Alt. Names/Synonyms: BSCL3; CAV; CAV1; caveolin 1; caveolin 1, caveolae protein, 22kDa; Caveolin-1; cell growth-inhibiting protein 32; CGL3; LCCNS; MSTP085; PPH3; VIP21
Gene Symbols: CAV1
Molecular weight: 20,472 Da
Basal Isoelectric point: 5.64  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  ErbB/HER Signaling  |  Insulin Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA