ABCC9 Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family
Chromosomal Location of human Ortholog: 12p12.1
Cellular Component:  inward rectifying potassium channel; membrane; plasma membrane; potassium ion-transporting ATPase complex; sarcomere
Molecular Function:  ABC-type transporter activity; ATP binding; ATP hydrolysis activity; ATP-activated inward rectifier potassium channel activity; ATPase-coupled inorganic anion transmembrane transporter activity; ATPase-coupled monoatomic cation transmembrane transporter activity; ATPase-coupled transmembrane transporter activity; monoatomic cation channel activity; potassium channel activity; potassium channel regulator activity; sulfonylurea receptor activity; transmembrane transporter activity; transmembrane transporter binding
Biological Process:  action potential; cardiac conduction; cardiac muscle cell contraction; coronary vasculature development; defense response to virus; fibroblast proliferation; heart morphogenesis; inorganic cation transmembrane transport; monoatomic anion transmembrane transport; monoatomic cation transmembrane transport; negative regulation of blood pressure; potassium ion import across plasma membrane; potassium ion transmembrane transport; regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization; response to ATP; response to xenobiotic stimulus; transmembrane transport; transport across blood-brain barrier
Disease: Atrial Fibrillation, Familial, 12; Cantu Syndrome; Cardiomyopathy, Dilated, 1o; Intellectual Disability And Myopathy Syndrome
Reference #:  O60706 (UniProtKB)
Alt. Names/Synonyms: ABC37; ABCC9; ATFB12; ATP binding cassette subfamily C member 9; ATP-binding cassette sub-family C member 9; ATP-binding cassette transporter sub-family C member 9; ATP-binding cassette, sub-family C (CFTR/MRP), member 9; CANTU; CMD1O; FLJ36852; Sulfonylurea receptor 2; sulfonylurea receptor 2A; SUR2
Gene Symbols: ABCC9
Molecular weight: 174,224 Da
Basal Isoelectric point: 7.05  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein