MS4A1 B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR. Belongs to the MS4A family. Expressed on B-cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell surface; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of mouse Ortholog: 19 A|19 8.19 cM
Cellular Component:  cell; cell surface; external side of plasma membrane; integral component of membrane; integral component of plasma membrane; membrane; nucleus; plasma membrane; plasma membrane raft
Molecular Function:  epidermal growth factor receptor binding; immunoglobulin binding; protein binding
Biological Process:  B cell activation; B cell differentiation; B cell receptor signaling pathway; calcium ion import into cytosol; protein tetramerization; response to bacterium; store-operated calcium entry
Reference #:  P19437 (UniProtKB)
Alt. Names/Synonyms: AA960661; B-cell differentiation antigen Ly-44; B-lymphocyte antigen CD20; Cd20; CD20 antigen; Ly-4; Ly-44; Lymphocyte antigen 44; Membrane-spanning 4-domains subfamily A member 1; membrane-spanning 4-domains, subfamily A, member 1; membrane-spanning 4-domains, subfamily A, member 2; Ms4a1; Ms4a2
Gene Symbols: Ms4a1
Molecular weight: 31,958 Da
Basal Isoelectric point: 5.22  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene