SRC-2 a transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Present in a complex with CARM1 and p300. Present in a complex containing NCOA3, IKKA, IKKB, IKBKG and CREBBP. Interacts with HIF1A, NCOA1, APEX and NR3C1. Interacts with CASP8AP2. Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the MYST3-NCOA2 oncogene, which consists of the N-terminus part of MYST3/MOZ and the C-terminus part of NCOA2/TIF2. MYST3-NCOA2 binds to CREBBP and disrupts its function in transcription activation. Phosphorylated and potentiated by the p38 MAPK signaling cascade in vitro and in vivo. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 1 A3|1 4.12 cM
Cellular Component:  cytoplasm; dendrite; dendritic spine; Golgi apparatus; microtubule; neuronal cell body; nuclear body; nucleoplasm; nucleus; postsynaptic density; presynaptic active zone; protein-containing complex; rough endoplasmic reticulum
Molecular Function:  aryl hydrocarbon receptor binding; chromatin binding; DNA polymerase binding; estrogen receptor binding; glucocorticoid receptor binding; nuclear hormone receptor binding; nuclear receptor binding; nuclear receptor transcription coactivator activity; PDZ domain binding; progesterone receptor binding; protein binding; protein dimerization activity; protein domain specific binding; protein-containing complex binding; retinoic acid receptor binding; retinoid X receptor binding; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding; RNA polymerase II proximal promoter sequence-specific DNA binding; signaling receptor binding; thyroid hormone receptor binding; thyroid hormone receptor coactivator activity; transcription coactivator activity; transcription factor binding
Biological Process:  cellular response to hormone stimulus; cellular response to Thyroglobulin triiodothyronine; circadian regulation of gene expression; circadian rhythm; locomotor rhythm; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; positive regulation of female receptivity; positive regulation of glucocorticoid receptor signaling pathway; positive regulation of transcription by RNA polymerase II; regulation of gene expression; regulation of glucose metabolic process; regulation of transcription, DNA-templated; response to progesterone; rhythmic process
Reference #:  Q61026 (UniProtKB)
Alt. Names/Synonyms: 9530095N19; bHLHe75; D1Ertd433e; glucocorticoid receptor interacting protein 1; Glucocorticoid receptor-interacting protein 1; GRIP-1; Grip1; KAT13C; NCoA-2; Ncoa2; Nuclear receptor coactivator 2; OTTMUSP00000024144; OTTMUSP00000024153; SRC-2; TIF-2; Tif2; TIF2/GRIP-1; Transcriptional intermediary factor 2
Gene Symbols: Ncoa2
Molecular weight: 158,466 Da
Basal Isoelectric point: 6.22  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA