SRC-2 Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer. Belongs to the SRC/p160 nuclear receptor coactivator family. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 1 A3|1 4.12 cM
Cellular Component:  cytoplasm; dendrite; dendritic spine; Golgi apparatus; microtubule; neuronal cell body; nuclear body; nucleoplasm; nucleus; postsynaptic density; presynaptic active zone; protein-containing complex; rough endoplasmic reticulum
Molecular Function:  aryl hydrocarbon receptor binding; chromatin binding; DNA polymerase binding; estrogen receptor binding; glucocorticoid receptor binding; nuclear hormone receptor binding; nuclear receptor binding; nuclear receptor transcription coactivator activity; PDZ domain binding; progesterone receptor binding; protein binding; protein dimerization activity; protein domain specific binding; protein-containing complex binding; retinoic acid receptor binding; retinoid X receptor binding; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding; RNA polymerase II proximal promoter sequence-specific DNA binding; signaling receptor binding; thyroid hormone receptor binding; thyroid hormone receptor coactivator activity; transcription coactivator activity; transcription factor binding
Biological Process:  cellular response to hormone stimulus; cellular response to Thyroglobulin triiodothyronine; circadian regulation of gene expression; circadian rhythm; locomotor rhythm; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; positive regulation of female receptivity; positive regulation of glucocorticoid receptor signaling pathway; positive regulation of transcription by RNA polymerase II; regulation of gene expression; regulation of glucose metabolic process; regulation of transcription, DNA-templated; response to progesterone; rhythmic process
Reference #:  Q61026 (UniProtKB)
Alt. Names/Synonyms: 9530095N19; bHLHe7; bHLHe75; D1Ertd433; D1Ertd433e; glucocorticoid receptor interacting protein 1; Glucocorticoid receptor-interacting protein 1; GRIP-1; Grip1; KAT13; KAT13C; NCoA-2; Ncoa2; Nuclear receptor coactivator 2; OTTMUSP00000024144; OTTMUSP00000024153; SRC; SRC-2; Src2; Steroid receptor coactivator 2; TIF; TIF-; TIF-2; Tif2; TIF2/GR; TIF2/GRIP-1; Transcriptional intermediary factor 2
Gene Symbols: Ncoa2
Molecular weight: 158,466 Da
Basal Isoelectric point: 6.22  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA