SRC-2 Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer. Belongs to the SRC/p160 nuclear receptor coactivator family. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of human Ortholog: 8q13.3
Cellular Component:  chromatin; cytoplasm; nuclear body; nucleoplasm; nucleus; protein-containing complex; RNA polymerase II transcription regulator complex; transcription regulator complex
Molecular Function:  aryl hydrocarbon receptor binding; chromatin binding; nuclear receptor binding; nuclear receptor coactivator activity; protein binding; protein dimerization activity; protein domain specific binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding; transcription coactivator activity
Biological Process:  cellular response to hormone stimulus; cellular response to Thyroglobulin triiodothyronine; circadian regulation of gene expression; locomotor rhythm; mRNA transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase II; peroxisome proliferator activated receptor signaling pathway; positive regulation of adipose tissue development; positive regulation of transcription by RNA polymerase II; regulation of cellular response to insulin stimulus; regulation of DNA-templated transcription; regulation of glucose metabolic process; regulation of lipid metabolic process; response to progesterone
Reference #:  Q15596 (UniProtKB)
Alt. Names/Synonyms: BHLHE75; Class E basic helix-loop-helix protein 75; glucocorticoid receptor-interacting protein-1; GRIP1; hTIF2; KAT13C; MGC138808; NCoA-2; NCOA2; Nuclear receptor coactivator 2; p160 steroid receptor coactivator 2; SRC-2; SRC2; steroid receptor coactivator-2; TIF2; Transcriptional intermediary factor 2
Gene Symbols: NCOA2
Molecular weight: 159,157 Da
Basal Isoelectric point: 6.19  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.