GPR132 May be a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids such as 9-hydroxyoctadecadienoic acid (9-HODE). Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May function as a sensor that monitors the oxidative states and mediates appropriate cellular responses such as secretion of paracrine signals and attenuation of proliferation. May mediate ths accumulation of intracellular inositol phosphates at acidic pH through proton-sensing activity. Belongs to the G-protein coupled receptor 1 family. Highly expressed in macrophages and hematopoietic tissues rich in lymphocytes, like spleen and thymus. Weakly expressed in heart and lung. In atherosclerotic plaques, expression is observed around the lipid core and at the shoulder region. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of mouse Ortholog: 12|12 F1
Cellular Component:  membrane; plasma membrane
Molecular Function:  G protein-coupled receptor activity
Biological Process:  G protein-coupled receptor signaling pathway; G1/S transition of mitotic cell cycle; negative regulation of G2/M transition of mitotic cell cycle; signal transduction
Reference #:  Q9Z282 (UniProtKB)
Alt. Names/Synonyms: G protein-coupled receptor 132; G protein-coupled receptor G2A; G2 accumulation protein; G2a; GP132; Gpr132; Probable G-protein coupled receptor 132
Gene Symbols: Gpr132
Molecular weight: 42,653 Da
Basal Isoelectric point: 8.47  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein