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UCHL1
Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity. Belongs to the peptidase C12 family. Found in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients. Note: This description may include information from UniProtKB.
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| Protein type: Cell development/differentiation; EC 3.4.19.12; Ligase; Protease; Ubiquitin conjugating system |
| Chromosomal Location of mouse Ortholog: 5 C3.1|5 35.95 cM |
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Cellular Component:
axon; cytoplasm; cytosol; endoplasmic reticulum; membrane; neuron projection terminus; neuronal cell body; nucleoplasm; plasma membrane
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Molecular Function:
alpha-2A adrenergic receptor binding; cysteine-type deubiquitinase activity; cysteine-type endopeptidase activity; cysteine-type peptidase activity; hydrolase activity; omega peptidase activity; peptidase activity; ubiquitin binding; ubiquitin protein ligase binding
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Biological Process:
adult walking behavior; axon target recognition; axonal transport of mitochondrion; axonogenesis; cellular response to xenobiotic stimulus; eating behavior; male germ cell proliferation; muscle cell development; negative regulation of MAP kinase activity; neuromuscular process; protein deubiquitination; proteolysis; response to ischemia; ubiquitin-dependent protein catabolic process
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Reference #:
Q9R0P9
(UniProtKB)
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Alt. Names/Synonyms: AW822034; C88048; gad; gracile axonal dystrophy; Neuron cytoplasmic protein 9.5; PGP 9.5; PGP9; PGP9.5; protein gene product 9.5; R75593; ubiquitin carboxy-terminal hydrolase L1; Ubiquitin carboxyl-terminal hydrolase isozyme L1; Ubiquitin thioesterase L1; UCH-L1; UCHL-1; Uchl1
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Gene Symbols: Uchl1
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Molecular weight:
24,838 Da
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Basal Isoelectric point:
5.14
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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