CDC42EP4 Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts. Belongs to the BORG/CEP family. Not detected in any of the adult tissues tested. May be expressed only in fetal or embryonic tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 17q25.1
Cellular Component:  actin cytoskeleton; cell-cell adherens junction; endomembrane system; microtubule cytoskeleton; phagocytic vesicle; plasma membrane
Molecular Function:  GTP-Rho binding; protein binding
Biological Process:  cellular response to interferon-gamma; positive regulation of pseudopodium assembly; regulation of cell shape
Reference #:  Q9H3Q1 (UniProtKB)
Alt. Names/Synonyms: Binder of Rho GTPases 4; BORG4; CDC42 effector protein (Rho GTPase binding) 4; Cdc42 effector protein 4; CDC42EP4; CEP4; KAIA1777; MGC17125; MGC3740
Gene Symbols: CDC42EP4
Molecular weight: 37,980 Da
Basal Isoelectric point: 5.05  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene