RAPGEF1 Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth. Ubiquitously expressed in adult and fetus. Expression is high in adult skeletal muscle and placenta and in fetal brain and heart. Low levels of expression in adult and fetal liver. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Ras; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 9q34.13
Cellular Component:  cytoplasm; cytosol; early endosome; perinuclear region of cytoplasm; phagocytic vesicle membrane; protein-containing complex
Molecular Function:  guanyl-nucleotide exchange factor activity; protein binding; Rap guanyl-nucleotide exchange factor activity; SH3 domain binding
Biological Process:  activation of GTPase activity; activation of MAPKK activity; blood vessel development; cell-cell adhesion; cellular response to cAMP; cellular response to nerve growth factor stimulus; cytokine-mediated signaling pathway; establishment of endothelial barrier; negative regulation of canonical Wnt signaling pathway; negative regulation of ERK1 and ERK2 cascade; negative regulation of neural precursor cell proliferation; negative regulation of protein kinase B signaling; negative regulation of Ras protein signal transduction; nerve growth factor signaling pathway; platelet-derived growth factor receptor signaling pathway; positive regulation of ERK1 and ERK2 cascade; positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis; positive regulation of GTPase activity; positive regulation of neuron projection development; positive regulation of Ras protein signal transduction; Rap protein signal transduction; regulation of cell junction assembly; regulation of JNK cascade; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  Q13905 (UniProtKB)
Alt. Names/Synonyms: C3G; CRK SH3-binding GNRP; DKFZp781P1719; GRF2; Guanine nucleotide-releasing factor 2; guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene); Protein C3G; Rap guanine nucleotide exchange factor (GEF) 1; Rap guanine nucleotide exchange factor 1; RAPGEF1; RPGF1
Gene Symbols: RAPGEF1
Molecular weight: 120,548 Da
Basal Isoelectric point: 5.64  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Growth And Differentiation Control by MAPKs  |  Insulin Receptor Signaling
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein