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PROX1
Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3. Belongs to the Prospero homeodomain family. Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Nuclear receptor co-regulator; Transcription factor |
| Chromosomal Location of human Ortholog: 1q32.3 |
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Cellular Component:
chromatin; cytoplasm; cytosol; nucleoplasm; nucleus
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Molecular Function:
DNA binding; DNA binding domain binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; LBD domain binding; nuclear receptor binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding
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Biological Process:
acinar cell differentiation; aorta smooth muscle tissue morphogenesis; atrial cardiac muscle tissue morphogenesis; blood vessel endothelial cell differentiation; brain development; branching involved in pancreas morphogenesis; cerebellar granule cell differentiation; circadian rhythm; dentate gyrus development; dorsal spinal cord development; embryonic retina morphogenesis in camera-type eye; endocardium formation; epithelial cell migration; hepatocyte cell migration; hepatocyte differentiation; hepatocyte proliferation; kidney development; lens development in camera-type eye; lens fiber cell morphogenesis; lens placode formation involved in camera-type eye formation; liver development; lung development; lymphangiogenesis; lymphatic endothelial cell differentiation; lymphatic endothelial cell fate commitment; negative regulation of bile acid biosynthetic process; negative regulation of cell population proliferation; negative regulation of DNA-binding transcription factor activity; negative regulation of DNA-templated transcription; negative regulation of neuroblast proliferation; negative regulation of transcription by RNA polymerase II; negative regulation of viral genome replication; neural tube development; neuroblast proliferation; neuron fate determination; neuronal stem cell population maintenance; olfactory placode formation; otic placode formation; pancreas development; positive regulation of cell cycle; positive regulation of cell cycle checkpoint; positive regulation of cell population proliferation; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of forebrain neuron differentiation; positive regulation of heart growth; positive regulation of neural precursor cell proliferation; positive regulation of sarcomere organization; positive regulation of transcription by RNA polymerase II; regulation of circadian rhythm; regulation of gene expression; regulation of transcription by RNA polymerase II; response to nutrient levels; retina morphogenesis in camera-type eye; skeletal muscle thin filament assembly; transcription by RNA polymerase II; venous blood vessel morphogenesis; ventricular cardiac muscle tissue morphogenesis; ventricular cardiac myofibril assembly; ventricular septum morphogenesis
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Reference #:
Q92786
(UniProtKB)
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Alt. Names/Synonyms: Homeobox prospero-like protein PROX1; prospero homeobox 1; Prospero homeobox protein 1; prospero-related homeobox 1; PROX-1; PROX1
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Gene Symbols: PROX1
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Molecular weight:
83,203 Da
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Basal Isoelectric point:
6.74
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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