PROX1 Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3. Belongs to the Prospero homeodomain family. Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor co-regulator; Transcription factor
Chromosomal Location of Human Ortholog: 1q32.3
Cellular Component:  cytoplasm; nucleus
Molecular Function:  DBD domain binding; DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; LBD domain binding; nuclear receptor binding; protein binding; RNA polymerase II proximal promoter sequence-specific DNA binding; transcription regulatory region DNA binding
Biological Process:  acinar cell differentiation; aorta smooth muscle tissue morphogenesis; atrial cardiac muscle tissue morphogenesis; brain development; branching involved in pancreas morphogenesis; cell fate determination; cerebellar granule cell differentiation; circadian rhythm; dentate gyrus development; dorsal spinal cord development; embryonic retina morphogenesis in camera-type eye; endocardium formation; hepatocyte cell migration; hepatocyte differentiation; hepatocyte proliferation; kidney development; lens development in camera-type eye; lens fiber cell morphogenesis; liver development; lung development; lymphangiogenesis; lymphatic endothelial cell differentiation; negative regulation of bile acid biosynthetic process; negative regulation of cell proliferation; negative regulation of DNA-binding transcription factor activity; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; negative regulation of viral genome replication; neural tube development; neuronal stem cell population maintenance; olfactory placode formation; optic placode formation involved in camera-type eye formation; otic placode formation; pancreas development; positive regulation of cell cycle; positive regulation of cell cycle checkpoint; positive regulation of cell proliferation; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of forebrain neuron differentiation; positive regulation of heart growth; positive regulation of neural precursor cell proliferation; positive regulation of sarcomere organization; positive regulation of transcription, DNA-templated; regulation of circadian rhythm; regulation of gene expression; regulation of transcription involved in lymphatic endothelial cell fate commitment; response to nutrient levels; retina morphogenesis in camera-type eye; skeletal muscle thin filament assembly; venous blood vessel morphogenesis; ventricular cardiac muscle tissue morphogenesis; ventricular cardiac myofibril assembly; ventricular septum morphogenesis
Reference #:  Q92786 (UniProtKB)
Alt. Names/Synonyms: Homeobox prospero-like protein PROX1; prospero homeobox 1; Prospero homeobox protein 1; prospero-related homeobox 1; PROX-1; PROX1
Gene Symbols: PROX1
Molecular weight: 83,203 Da
Basal Isoelectric point: 6.74  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA