UBXN4 Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD. Expressed in many tissues, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Accumulates in Alzheimer disease-afflicted brains (at protein level). Note: This description may include information from UniProtKB.
Protein type: Chaperone; Endoplasmic reticulum; Membrane protein, integral; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 1|1 E3
Cellular Component:  cytosol; endoplasmic reticulum; membrane; nucleus
Biological Process:  response to unfolded protein; ubiquitin-dependent ERAD pathway
Reference #:  Q8VCH8 (UniProtKB)
Alt. Names/Synonyms: 1300013G12Rik; Erasin; KIAA0242; mKIAA0242; UBX domain containing 2; UBX domain protein 4; UBX domain-containing protein 2; UBX domain-containing protein 4; Ubxd2; Ubxdc1; Ubxn4
Gene Symbols: Ubxn4
Molecular weight: 56,472 Da
Basal Isoelectric point: 6.23  Predict pI for various phosphorylation states
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UBXN4

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene