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UBXN4
Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD. Expressed in many tissues, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Accumulates in Alzheimer disease-afflicted brains (at protein level). Note: This description may include information from UniProtKB.
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| Protein type: Chaperone; Endoplasmic reticulum; Membrane protein, integral; Ubiquitin conjugating system |
| Chromosomal Location of mouse Ortholog: 1|1 E3 |
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Cellular Component:
cytosol; endoplasmic reticulum; membrane; nucleus
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Biological Process:
response to unfolded protein; ubiquitin-dependent ERAD pathway
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Reference #:
Q8VCH8
(UniProtKB)
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Alt. Names/Synonyms: 1300013G12Rik; Erasin; KIAA0242; mKIAA0242; UBX domain containing 2; UBX domain protein 4; UBX domain-containing protein 2; UBX domain-containing protein 4; Ubxd2; Ubxdc1; Ubxn4
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Gene Symbols: Ubxn4
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Molecular weight:
56,472 Da
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Basal Isoelectric point:
6.23
Predict pI for various phosphorylation states
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