RAD51D Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Defects in RAD51D are a cause of susceptibility to familial breast-ovarian cancer type 4 (BROVCA4). A condition associated with familial predisposition to cancer of the breast and ovaries. Characteristic features in affected families are an early age of onset of breast cancer (often before age 50), increased chance of bilateral cancers (cancer that develop in both breasts, or both ovaries, independently), frequent occurrence of breast cancer among men, increased incidence of tumors of other specific organs, such as the prostate. Belongs to the RecA family. RAD51 subfamily. 8 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 17q12
Cellular Component:  centrosome; chromosome, telomeric region; cytoplasm; nuclear chromosome, telomeric region; nucleoplasm; nucleus; Rad51B-Rad51C-Rad51D-XRCC2 complex; replication fork
Molecular Function:  ATP binding; DNA binding; DNA-dependent ATPase activity; gamma-tubulin binding; protein binding; single-stranded DNA binding
Biological Process:  DNA repair; double-strand break repair via homologous recombination; interstrand cross-link repair; reciprocal meiotic recombination; regulation of cell cycle; strand invasion; telomere maintenance
Disease: Breast-ovarian Cancer, Familial, Susceptibility To, 4
Reference #:  O75771 (UniProtKB)
Alt. Names/Synonyms: DNA repair protein RAD51 homolog 4; HsTRAD; R51H3; RA51D; RAD51 homolog D; RAD51-like 3 (S. cerevisiae); RAD51-like protein 3; RAD51D; RAD51L3; recombination repair protein; TRAD
Gene Symbols: RAD51D
Molecular weight: 35,049 Da
Basal Isoelectric point: 5.89  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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