NME5
Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species. Belongs to the NDK family. Specifically expressed in testis germinal cells. Note: This description may include information from UniProtKB.
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Protein type: Kinase, nucleoside diphosphate; Kinase, other; NDK family; Other group |
Chromosomal Location of human Ortholog: 5q31.2 |
Cellular Component:
9+2 motile cilium; cilium; cytoplasm; cytoskeleton; extracellular region; sperm flagellum
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Molecular Function:
nucleoside diphosphate kinase activity; protein binding
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Biological Process:
cilium assembly; cilium movement; CTP biosynthetic process; epithelial cilium movement involved in extracellular fluid movement; establishment of localization in cell; GTP biosynthetic process; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; nucleoside metabolic process; spermatid development; spermatogenesis; UTP biosynthetic process; ventricular system development
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Disease: Ciliary Dyskinesia, Primary, 48, Without Situs Inversus
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Reference #:
P56597
(UniProtKB)
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Alt. Names/Synonyms: Inhibitor of p53-induced apoptosis-beta; IPIA-beta; NDK-H 5; NDK5; NDP kinase homolog 5; nm23-H5; NM23H5; NME/NM23 family member 5; NME5; non-metastatic cells 5 protein expressed in; non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase); Nucleoside diphosphate kinase homolog 5; radial spoke 23 homolog; RSPH23; Testis-specific nm23 homolog
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Gene Symbols: NME5
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Molecular weight:
24,236 Da
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Basal Isoelectric point:
5.89
Predict pI for various phosphorylation states
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