NME5 Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species. Belongs to the NDK family. Specifically expressed in testis germinal cells. Note: This description may include information from UniProtKB.
Protein type: Kinase, nucleoside diphosphate; Kinase, other; NDK family; Other group
Chromosomal Location of human Ortholog: 5q31.2
Cellular Component:  9+2 motile cilium; cilium; cytoplasm; cytoskeleton; extracellular region; sperm flagellum
Molecular Function:  nucleoside diphosphate kinase activity; protein binding
Biological Process:  cilium assembly; cilium movement; CTP biosynthetic process; epithelial cilium movement involved in extracellular fluid movement; establishment of localization in cell; GTP biosynthetic process; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; nucleoside metabolic process; spermatid development; spermatogenesis; UTP biosynthetic process; ventricular system development
Disease: Ciliary Dyskinesia, Primary, 48, Without Situs Inversus
Reference #:  P56597 (UniProtKB)
Alt. Names/Synonyms: Inhibitor of p53-induced apoptosis-beta; IPIA-beta; NDK-H 5; NDK5; NDP kinase homolog 5; nm23-H5; NM23H5; NME/NM23 family member 5; NME5; non-metastatic cells 5 protein expressed in; non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase); Nucleoside diphosphate kinase homolog 5; radial spoke 23 homolog; RSPH23; Testis-specific nm23 homolog
Gene Symbols: NME5
Molecular weight: 24,236 Da
Basal Isoelectric point: 5.89  Predict pI for various phosphorylation states
Select Structure to View Below

NME5

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein