CCR1 Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation. Belongs to the G-protein coupled receptor 1 family. Widely expressed in different hematopoietic cells. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR
Chromosomal Location of Human Ortholog: 9 F4|9 75.05 cM
Cellular Component:  cytoplasm; external side of plasma membrane; integral component of membrane; membrane; neuronal cell body; plasma membrane
Molecular Function:  C-C chemokine binding; C-C chemokine receptor activity; chemokine (C-C motif) ligand 5 binding; chemokine (C-C motif) ligand 7 binding; chemokine binding; chemokine receptor activity; G protein-coupled receptor activity; phosphatidylinositol phospholipase C activity; protein binding
Biological Process:  calcium ion transport; calcium-mediated signaling; cell chemotaxis; cell-cell signaling; cellular calcium ion homeostasis; chemokine-mediated signaling pathway; chemotaxis; exocytosis; G protein-coupled receptor signaling pathway; immune response; inflammatory response; leukocyte chemotaxis; myeloid cell differentiation; negative regulation of bone mineralization; negative regulation of gene expression; negative regulation of innate immune response; positive regulation of calcium ion transport; positive regulation of cell migration; positive regulation of cytosolic calcium ion concentration; positive regulation of ERK1 and ERK2 cascade; positive regulation of monocyte chemotaxis; positive regulation of osteoclast differentiation; signal transduction
Reference #:  P51675 (UniProtKB)
Alt. Names/Synonyms: C-C chemokine receptor type 1; C-C CKR-1; CC-CKR-1; CCR-1; CCR1; CD191; chemokine (C-C motif) receptor 1; chemokine (C-C) receptor 1; Cmkbr; Cmkbr1; Macrophage inflammatory protein 1-alpha receptor; MIP-1 alpha R; MIP-1 alphaR; Mip-1a-R; MIP-1alpha-R; RANTES-R
Gene Symbols: Ccr1
Molecular weight: 40,895 Da
Basal Isoelectric point: 8.97  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene