CCR1 Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation. Belongs to the G-protein coupled receptor 1 family. Widely expressed in different hematopoietic cells. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR
Chromosomal Location of Human Ortholog: 3p21.31
Cellular Component:  external side of plasma membrane; integral component of plasma membrane; plasma membrane
Molecular Function:  C-C chemokine binding; C-C chemokine receptor activity; chemokine (C-C motif) ligand 5 binding; chemokine (C-C motif) ligand 7 binding; chemokine receptor activity; phosphatidylinositol phospholipase C activity; protein binding
Biological Process:  calcium ion transport; cell adhesion; cell surface receptor signaling pathway; cell-cell signaling; cellular calcium ion homeostasis; chemokine-mediated signaling pathway; chemotaxis; cytokine-mediated signaling pathway; dendritic cell chemotaxis; exocytosis; G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; immune response; negative regulation of bone mineralization; negative regulation of gene expression; positive regulation of calcium ion transport; positive regulation of cell migration; positive regulation of cytosolic calcium ion concentration; positive regulation of ERK1 and ERK2 cascade; positive regulation of monocyte chemotaxis; positive regulation of osteoclast differentiation; response to wounding
Reference #:  P32246 (UniProtKB)
Alt. Names/Synonyms: C-C chemokine receptor type 1; C-C CKR-1; C-C motif chemokine receptor 1; CC-CKR-1; CCR-1; CCR1; CD191; chemokine (C-C motif) receptor 1; CKR-1; CKR1; CMKBR1; CMKR1; HM145; LD78 receptor; Macrophage inflammatory protein 1-alpha receptor; MIP-1alpha-R; MIP1aR; RANTES receptor; RANTES-R; SCYAR1
Gene Symbols: CCR1
Molecular weight: 41,173 Da
Basal Isoelectric point: 8.38  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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