STIM1 Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit ORAI1. Involved in enamel formation. Activated following interaction with STIMATE, leading to promote STIM1 conformational switch. Ubiquitously expressed in various human primary cells and tumor cell lines. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Calcium-binding; Endoplasmic reticulum; Membrane protein, integral
Chromosomal Location of Human Ortholog: 11p15.4
Cellular Component:  cortical endoplasmic reticulum; endoplasmic reticulum; endoplasmic reticulum membrane; integral component of endoplasmic reticulum membrane; integral component of plasma membrane; microtubule; plasma membrane; plasma membrane raft; sarcoplasmic reticulum membrane
Molecular Function:  calcium channel regulator activity; calcium ion binding; identical protein binding; microtubule plus-end binding; protease binding; protein binding
Biological Process:  activation of store-operated calcium channel activity; detection of calcium ion; enamel mineralization; positive regulation of adenylate cyclase activity; positive regulation of angiogenesis; regulation of calcium ion transport; regulation of cardiac conduction; regulation of store-operated calcium entry; store-operated calcium entry
Disease: Immunodeficiency 10; Myopathy, Tubular Aggregate, 1; Stormorken Syndrome
Reference #:  Q13586 (UniProtKB)
Alt. Names/Synonyms: D11S4896E; GOK; IMD10; STIM1; STRMK; Stromal interaction molecule 1; TAM; TAM1
Gene Symbols: STIM1
Molecular weight: 77,423 Da
Basal Isoelectric point: 6.19  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene