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STIM1
Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit ORAI1. Involved in enamel formation. Activated following interaction with STIMATE, leading to promote STIM1 conformational switch. Ubiquitously expressed in various human primary cells and tumor cell lines. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Calcium-binding; Endoplasmic reticulum; Membrane protein, integral |
| Chromosomal Location of Human Ortholog: 11p15.4 |
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Cellular Component:
cortical endoplasmic reticulum; endoplasmic reticulum; endoplasmic reticulum membrane; integral component of endoplasmic reticulum membrane; integral component of plasma membrane; microtubule; plasma membrane; plasma membrane raft; sarcoplasmic reticulum membrane
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Molecular Function:
calcium channel regulator activity; calcium ion binding; identical protein binding; microtubule plus-end binding; protease binding; protein binding
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Biological Process:
activation of store-operated calcium channel activity; detection of calcium ion; enamel mineralization; positive regulation of adenylate cyclase activity; positive regulation of angiogenesis; regulation of calcium ion transport; regulation of cardiac conduction; regulation of store-operated calcium entry; store-operated calcium entry
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Disease: Immunodeficiency 10; Myopathy, Tubular Aggregate, 1; Stormorken Syndrome
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Reference #:
Q13586
(UniProtKB)
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Alt. Names/Synonyms: D11S4896E; GOK; IMD10; STIM1; STRMK; Stromal interaction molecule 1; TAM; TAM1
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Gene Symbols: STIM1
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Molecular weight:
77,423 Da
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Basal Isoelectric point:
6.19
Predict pI for various phosphorylation states
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CST Pathways:
B Cell Receptor Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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