HIP One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins. Belongs to the FAM10 family. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Chaperone
Chromosomal Location of Human Ortholog: 22q13.2
Cellular Component:  cytoplasm; cytosol; protein-containing complex
Molecular Function:  chaperone binding; dATP binding; Hsp70 protein binding; identical protein binding; protein binding; protein binding, bridging; protein dimerization activity; protein domain specific binding; protein-containing complex binding; unfolded protein binding
Biological Process:  negative regulation of protein refolding; protein folding; protein homotetramerization; response to bacterium
Reference #:  P50502 (UniProtKB)
Alt. Names/Synonyms: AAG2; aging-associated protein 2; F10A1; FAM10A1; FAM10A4; FLJ27260; heat shock 70kD protein binding protein; HIP; HOP; Hsc70-interacting protein; Hsp70-interacting protein; HSPABP; HSPABP1; MGC129952; P48; PRO0786; Progesterone receptor-associated p48 protein; Protein FAM10A1; Putative tumor suppressor ST13; Renal carcinoma antigen NY-REN-33; SNC6; ST13; ST13 Hsp70 interacting protein; suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein); Suppression of tumorigenicity 13 protein; testis secretory sperm-binding protein Li 233m
Gene Symbols: ST13
Molecular weight: 41,332 Da
Basal Isoelectric point: 5.18  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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HIP

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB