C/EBP-beta an important bZIP transcription factor that regulates the expression of genes involved in immune and inflammatory responses. Plays also a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant functions with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Plays also a role in intracellular bacteria killing. During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation. Essential for female reproduction because of a critical role in ovarian follicle development. Restricts osteoclastogenesis: together with NFE2L1; represses expression of DSPP during odontoblast differentiation. Isoform 2: Essential for gene expression induction in activated macrophages. Plays a major role in immune responses such as CD4(+) T-cell response, granuloma formation and endotoxin shock. Not essential for intracellular bacteria killing. Isoform 3: Acts as a dominant negative through heterodimerization with isoform 2. Promotes osteoblast differentiation and osteoclastogenesis. Belongs to the bZIP family. C/EBP subfamily. Expressed at low levels in the lung, kidney and spleen. 3 alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Motility/polarity/chemotaxis; Transcription factor
Chromosomal Location of Human Ortholog: 2 H3|2 87.58 cM
Cellular Component:  CHOP-C/EBP complex; condensed chromosome, centromeric region; cytoplasm; nuclear chromatin; nuclear matrix; nucleoplasm; nucleus; RNA polymerase II transcription factor complex
Molecular Function:  chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; glucocorticoid receptor binding; histone acetyltransferase binding; histone deacetylase binding; kinase binding; protein binding; protein heterodimerization activity; protein homodimerization activity; RNA polymerase II core promoter sequence-specific DNA binding; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II regulatory region sequence-specific DNA binding; sequence-specific DNA binding; transcription factor binding; transcription regulatory region DNA binding; ubiquitin-like protein ligase binding
Biological Process:  brown fat cell differentiation; cell differentiation; cellular response to amino acid stimulus; cellular response to interleukin-1; cellular response to lipopolysaccharide; defense response to bacterium; embryonic placenta development; fat cell differentiation; granuloma formation; hepatocyte proliferation; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; liver regeneration; mammary gland epithelial cell differentiation; mammary gland epithelial cell proliferation; negative regulation of neuron apoptotic process; negative regulation of T cell proliferation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; neuron differentiation; ovarian follicle development; positive regulation of biomineral tissue development; positive regulation of cold-induced thermogenesis; positive regulation of fat cell differentiation; positive regulation of inflammatory response; positive regulation of interleukin-4 production; positive regulation of osteoblast differentiation; positive regulation of sodium-dependent phosphate transport; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; positive regulation of transcription, DNA-templated; regulation of dendritic cell differentiation; regulation of interleukin-6 biosynthetic process; regulation of odontoblast differentiation; regulation of osteoclast differentiation; regulation of transcription involved in cell fate commitment; regulation of transcription, DNA-templated; response to endoplasmic reticulum stress; response to lipopolysaccharide; T-helper 1 cell activation
Reference #:  P28033 (UniProtKB)
Alt. Names/Synonyms: AGP/EBP; C/EBP beta; C/EBP-beta; C/EBPbe; C/EBPbeta; CCAAT/enhancer binding protein (C/EBP), beta; CCAAT/enhancer-binding protein beta; Cebpb; CRP2; IL-6; IL-6DBP; Interleukin-6-dependent-binding protein; LAP; LIP; Liver-enriched transcriptional activator; NF-; NF-IL6; NF-M; Nfil6; nuclear protein Il6; OTTMUSP00000017503
Gene Symbols: Cebpb
Molecular weight: 31,446 Da
Basal Isoelectric point: 8.78  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Growth And Differentiation Control by MAPKs  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene