SFTPC Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Lipid-binding
Chromosomal Location of human Ortholog: 8p21.3
Cellular Component:  alveolar lamellar body; clathrin-coated endocytic vesicle; endoplasmic reticulum membrane; extracellular region; extracellular space; lamellar body; multivesicular body lumen
Molecular Function:  identical protein binding; protein binding
Biological Process:  respiratory gaseous exchange by respiratory system
Disease: Pulmonary Fibrosis, Idiopathic; Surfactant Metabolism Dysfunction, Pulmonary, 2
Reference #:  P11686 (UniProtKB)
Alt. Names/Synonyms: BRICD6; BRICHOS domain containing 6; PSP-C; PSPC; pulmonary surfactant apoprotein-2 SP-C; Pulmonary surfactant-associated protein C; Pulmonary surfactant-associated proteolipid SPL(Val); SFTP2; SFTPC; SMDP2; SP-C; SP5; surfactant protein C
Gene Symbols: SFTPC
Molecular weight: 21,013 Da
Basal Isoelectric point: 6.19  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein