|
SFTPC
Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Lipid-binding |
| Chromosomal Location of human Ortholog: 8p21.3 |
|
Cellular Component:
alveolar lamellar body; clathrin-coated endocytic vesicle; endoplasmic reticulum membrane; extracellular region; extracellular space; lamellar body; multivesicular body lumen
|
|
Molecular Function:
identical protein binding; protein binding
|
|
Biological Process:
respiratory gaseous exchange by respiratory system
|
|
Disease: Pulmonary Fibrosis, Idiopathic; Surfactant Metabolism Dysfunction, Pulmonary, 2
|
|
Reference #:
P11686
(UniProtKB)
|
|
Alt. Names/Synonyms: BRICD6; BRICHOS domain containing 6; PSP-C; PSPC; pulmonary surfactant apoprotein-2 SP-C; Pulmonary surfactant-associated protein C; Pulmonary surfactant-associated proteolipid SPL(Val); SFTP2; SFTPC; SMDP2; SP-C; SP5; surfactant protein C
|
|
Gene Symbols: SFTPC
|
|
Molecular weight:
21,013 Da
|
|
Basal Isoelectric point:
6.19
Predict pI for various phosphorylation states
|
