IPO8 Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates the nuclear import of SRP19. Belongs to the importin beta family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: G protein regulator, misc.; Karyopherin; Nuclear export; Nuclear import
Chromosomal Location of Human Ortholog: 6|6 G3
Cellular Component:  cytoplasm; cytosol; integral component of plasma membrane; nuclear envelope; nucleus
Molecular Function:  ATPase activity, coupled to transmembrane movement of substances; Ran GTPase binding
Biological Process:  intracellular protein transport; protein import into nucleus
Reference #:  Q7TMY7 (UniProtKB)
Alt. Names/Synonyms: 6230418K12Rik; Abcc10; ATP-binding cassette, sub-family C (CFTR/MRP), member 10; C130009K11Rik; Imp8; importin 8; Importin-8; Ipo8; MRP7; OM-1; Om1; oocyte maturation 1; OTTMUSP00000032125; Ran-binding protein 8; RanBP8
Gene Symbols: Ipo8
Molecular weight: 117,078 Da
Basal Isoelectric point: 5.04  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene