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IPO8
Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates the nuclear import of SRP19. Belongs to the importin beta family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: G protein regulator, misc.; Karyopherin; Nuclear export; Nuclear import |
| Chromosomal Location of mouse Ortholog: 6|6 G3 |
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Cellular Component:
cytoplasm; cytosol; nuclear envelope; nucleus; plasma membrane
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Molecular Function:
ATPase-coupled transmembrane transporter activity; small GTPase binding
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Biological Process:
intracellular protein transport; protein import into nucleus; protein transport; transmembrane transport; transport
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Reference #:
Q7TMY7
(UniProtKB)
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Alt. Names/Synonyms: 6230418K12Rik; Abcc10; ATP-binding cassette, sub-family C (CFTR/MRP), member 10; C130009K11Rik; Imp8; importin 8; Importin-8; Ipo8; MRP7; OM-; OM-1; Om1; oocyte maturation 1; OTTMUSP00000032125; Ran-binding protein 8; RanBP8
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Gene Symbols: Ipo8
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Molecular weight:
117,078 Da
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Basal Isoelectric point:
5.04
Predict pI for various phosphorylation states
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