ZC3H8 Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of human Ortholog: 2q14.1
Cellular Component:  Cajal body; histone locus body; nuclear body; nucleoplasm; nucleus; transcription elongation factor complex; transcriptionally active chromatin
Molecular Function:  DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; metal ion binding; protein binding; sequence-specific DNA binding
Biological Process:  apoptotic process; negative regulation of T cell differentiation in thymus; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; positive regulation of thymocyte apoptotic process; positive regulation of transcription by RNA polymerase III; response to antibiotic; snRNA transcription by RNA polymerase II; snRNA transcription by RNA polymerase III; T cell homeostasis
Reference #:  Q8N5P1 (UniProtKB)
Alt. Names/Synonyms: Fliz1; ZC3H8; ZC3HDC8; Zinc finger CCCH domain-containing protein 8; zinc finger CCCH type domain containing 8; zinc finger CCCH-type containing 8; zinc finger CCCH-type domain containing 8
Gene Symbols: ZC3H8
Molecular weight: 33,576 Da
Basal Isoelectric point: 8.55  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene