COL8A1 Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis. Vastatin, the C-terminal fragment comprising the NC1 domain, inhibits aortic endothelial cell proliferation and causes cell apoptosis. Expressed primarily in the subendothelium of large blood vessels. Also expressed in arterioles and venules in muscle, heart, kidney, spleen, umbilical cord, liver and lung and is also found in connective tissue layers around hair follicles, around nerve bundles in muscle, in the dura of the optic nerve, in cornea and sclera, and in the perichondrium of cartilaginous tissues. In the kidney, expressed in mesangial cells, glomerular endothelial cells, and tubular epithelial cells. Also expressed in mast cells, and in astrocytes during the repair process. Expressed in Descemet's membrane. Specifically expressed in peritoneal fibroblasts and mesothelial cells. Note: This description may include information from UniProtKB.
Protein type: Extracellular matrix; Secreted; Secreted, signal peptide
Chromosomal Location of mouse Ortholog: 16|16 C1.1
Cellular Component:  basement membrane; collagen trimer; collagen-containing extracellular matrix; extracellular region; extracellular space
Molecular Function:  extracellular matrix structural constituent conferring tensile strength
Biological Process:  angiogenesis; camera-type eye morphogenesis; cell adhesion; endothelial cell proliferation; extracellular matrix organization; positive regulation of cell-substrate adhesion
Reference #:  Q00780 (UniProtKB)
Alt. Names/Synonyms: CO8A1; Col8; Col8a-1; Col8a1; Collagen alpha-1(VIII) chain; collagen, type VIII, alpha 1; procollagen type VIII alpha 1; procollagen, type VIII, alpha 1; Vastatin
Gene Symbols: Col8a1
Molecular weight: 73,607 Da
Basal Isoelectric point: 9.56  Predict pI for various phosphorylation states
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COL8A1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein