COL8A1 Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis. Note: This description may include information from UniProtKB.
Protein type: Extracellular matrix; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 3q12.1
Cellular Component:  collagen type VIII trimer; endoplasmic reticulum lumen; extracellular region
Molecular Function:  extracellular matrix structural constituent conferring tensile strength; protein binding
Biological Process:  angiogenesis; camera-type eye morphogenesis; cell adhesion; endodermal cell differentiation; epithelial cell proliferation; extracellular matrix organization; positive regulation of cell-substrate adhesion
Reference #:  P27658 (UniProtKB)
Alt. Names/Synonyms: C3orf7; cell proliferation-inducing protein 41; CO8A1; COL8A1; Collagen alpha-1(VIII) chain; collagen VIII, alpha-1 polypeptide; collagen, type VIII, alpha 1; Endothelial collagen; MGC9568; smooth muscle cell-expressed and macrophage conditioned medium-induced protein smag-64; Vastatin
Gene Symbols: COL8A1
Molecular weight: 73,364 Da
Basal Isoelectric point: 9.62  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein