PLS3 Actin-bundling protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. May play a role in the regulation of bone development. Expressed in a variety of organs, including muscle, brain, uterus and esophagus. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: X|X A7.3
Cellular Component:  actin filament; actin filament bundle; cytoplasm; cytosol; neuromuscular junction; plasma membrane; stereocilium
Molecular Function:  actin binding; actin filament binding; calcium ion binding; metal ion binding; structural constituent of presynaptic actin cytoskeleton
Biological Process:  actin filament bundle assembly; actin filament network formation; bone development; regulation of synaptic vesicle cycle
Reference #:  Q99K51 (UniProtKB)
Alt. Names/Synonyms: AI115446; AL024105; OTTMUSP00000018963; OTTMUSP00000018964; OTTMUSP00000018965; plastin 3 (T-isoform); plastin 3, T; Plastin-3; Pls3; PLST; T-fim; T-fimbrin; T-plastin
Gene Symbols: Pls3
Molecular weight: 70,742 Da
Basal Isoelectric point: 5.42  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene