CACYBP May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Ubiquitin conjugating system
Chromosomal Location of human Ortholog: 1q25.1
Cellular Component:  beta-catenin destruction complex; cytosol; nuclear envelope lumen; nucleoplasm; nucleus; SCF ubiquitin ligase complex
Molecular Function:  protein binding; protein domain specific binding; protein homodimerization activity; S100 protein binding; tubulin binding; ubiquitin protein ligase binding
Biological Process:  cellular response to leukemia inhibitory factor; heart development
Reference #:  Q9HB71 (UniProtKB)
Alt. Names/Synonyms: CACYBP; calcyclin binding protein; Calcyclin-binding protein; CYBP; GIG5; growth-inhibiting gene 5 protein; hCacyBP; MGC87971; PNAS-107; RP1-102G20.6; S100A6-binding protein; S100A6BP; Siah-interacting protein; Siah-interacting protein (SIP); SIP
Gene Symbols: CACYBP
Molecular weight: 26,210 Da
Basal Isoelectric point: 8.28  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein