RABEP1 Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium. Belongs to the rabaptin family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 17p13.2
Cellular Component:  early endosome; early endosome membrane; endocytic vesicle; endosome; intracellular membrane-bounded organelle; protein-containing complex; recycling endosome
Molecular Function:  growth factor activity; GTPase activator activity; protein binding; protein domain specific binding; protein homodimerization activity
Biological Process:  apoptotic process; endocytosis; Golgi to plasma membrane transport; membrane fusion; positive regulation of GTPase activity; protein localization to ciliary membrane; protein transport; regulation of signaling receptor activity; vesicle-mediated transport
Reference #:  Q15276 (UniProtKB)
Alt. Names/Synonyms: neurocrescin; Rab GTPase-binding effector protein 1; RAB5EP; rabaptin, RAB GTPase binding effector protein 1; Rabaptin-4; Rabaptin-5; Rabaptin-5alpha; RABE1; RABEP1; RABPT5; RABPT5A; Renal carcinoma antigen NY-REN-17
Gene Symbols: RABEP1
Molecular weight: 99,290 Da
Basal Isoelectric point: 4.95  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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