BRCA1 E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator. Isoform 1 and isoform 3 are widely expressed. Isoform 3 is reduced or absent in several breast and ovarian cancer cell lines. 7 alternative splicing and alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 17q21.31
Cellular Component:  BRCA1-A complex; BRCA1-BARD1 complex; chromosome; cytoplasm; gamma-tubulin ring complex; lateral element; nucleoplasm; nucleus; plasma membrane; protein-containing complex; ribonucleoprotein complex; ubiquitin ligase complex
Molecular Function:  androgen receptor binding; damaged DNA binding; DNA binding; enzyme binding; identical protein binding; protein binding; RNA binding; RNA polymerase binding; transcription coactivator activity; transcription regulatory region DNA binding; tubulin binding; ubiquitin protein ligase binding; ubiquitin-protein transferase activity; zinc ion binding
Biological Process:  androgen receptor signaling pathway; apoptotic process; cellular response to DNA damage stimulus; cellular response to indole-3-methanol; cellular response to tumor necrosis factor; centrosome cycle; chromosome segregation; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; DNA double-strand break processing; DNA replication; double-strand break repair; double-strand break repair via homologous recombination; double-strand break repair via nonhomologous end joining; fatty acid biosynthetic process; intrinsic apoptotic signaling pathway in response to DNA damage; mitotic G2/M transition checkpoint; negative regulation of centriole replication; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of fatty acid biosynthetic process; negative regulation of G0 to G1 transition; negative regulation of histone H3-K4 methylation; negative regulation of histone H3-K9 methylation; negative regulation of intracellular estrogen receptor signaling pathway; negative regulation of reactive oxygen species metabolic process; negative regulation of transcription, DNA-templated; positive regulation of angiogenesis; positive regulation of cell cycle arrest; positive regulation of DNA repair; positive regulation of gene expression; positive regulation of histone acetylation; positive regulation of histone H3-K4 methylation; positive regulation of histone H3-K9 acetylation; positive regulation of histone H3-K9 methylation; positive regulation of histone H4-K16 acetylation; positive regulation of histone H4-K20 methylation; positive regulation of protein ubiquitination; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; positive regulation of vascular endothelial growth factor production; postreplication repair; protein autoubiquitination; protein deubiquitination; protein K6-linked ubiquitination; protein ubiquitination; regulation of apoptotic process; regulation of cell proliferation; regulation of DNA methylation; regulation of gene expression by genetic imprinting; regulation of signal transduction by p53 class mediator; regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase III; response to estrogen; response to ionizing radiation; signal transduction involved in G2 DNA damage checkpoint
Disease: Breast Cancer; Breast-ovarian Cancer, Familial, Susceptibility To, 1; Fanconi Anemia, Complementation Group S; Pancreatic Cancer, Susceptibility To, 4
Reference #:  P38398 (UniProtKB)
Alt. Names/Synonyms: BRCA1; BRCA1 DNA repair associated; BRCA1/BRCA2-containing complex, subunit 1; BRCAI; BRCC1; breast and ovarian cancer susceptibility protein 1; breast and ovarian cancer sususceptibility protein; breast cancer 1, early onset; Breast cancer type 1 susceptibility protein; BROVCA1; early onset breast cancer 1; Fanconi anemia, complementation group S; FANCS; IRIS; PNCA4; PPP1R53; protein phosphatase 1, regulatory subunit 53; PSCP; RING finger protein 53; RING-type E3 ubiquitin transferase BRCA1; RNF53
Gene Symbols: BRCA1
Molecular weight: 207,721 Da
Basal Isoelectric point: 5.29  Predict pI for various phosphorylation states
CST Pathways:  G2/M DNA Damage Checkpoint  |  Protein Acetylation
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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