NXF1 Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export. Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export. Belongs to the NXF family. Expressed ubiquitously. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA-binding
Chromosomal Location of Human Ortholog: 19 A|19 5.5 cM
Cellular Component:  cytoplasm; nuclear inclusion body; nuclear pore; nuclear speck; nucleoplasm; nucleus
Molecular Function:  mRNA binding; protein binding; RNA binding
Biological Process:  mRNA export from nucleus; poly(A)+ mRNA export from nucleus; RNA export from nucleus
Reference #:  Q99JX7 (UniProtKB)
Alt. Names/Synonyms: Mex 67 homolog; Mex67; modifier of vibrator 1; mRNA export factor TAP; Mvb; Mvb1; Nuclear RNA export factor 1; nuclear RNA export factor 1 homolog; nuclear RNA export factor 1 homolog (S. cerevisiae); Nxf1; Tap; tip associated protein; tip associating protein; Tip-associated protein; Tip-associating protein
Gene Symbols: Nxf1
Molecular weight: 70,300 Da
Basal Isoelectric point: 8.92  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene