|
NXF1
Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export. Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export. Belongs to the NXF family. Expressed ubiquitously. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: RNA-binding |
| Chromosomal Location of mouse Ortholog: 19 A|19 5.5 cM |
|
Cellular Component:
cytoplasm; nuclear inclusion body; nuclear pore; nuclear RNA export factor complex; nuclear speck; nucleoplasm; nucleus; transcription export complex
|
|
Molecular Function:
mRNA binding; nucleic acid binding; protein binding; RNA binding
|
|
Biological Process:
mRNA export from nucleus; mRNA transport; poly(A)+ mRNA export from nucleus; protein transport; RNA export from nucleus
|
|
Reference #:
Q99JX7
(UniProtKB)
|
|
Alt. Names/Synonyms: Mex 67 homolog; Mex67; modifier of vibrator 1; mRNA export factor TAP; Mvb; Mvb1; Nuclear RNA export factor 1; nuclear RNA export factor 1 homolog; nuclear RNA export factor 1 homolog (S. cerevisiae); Nxf1; Tap; tip associated protein; tip associating protein; Tip-associated protein; Tip-associating protein
|
|
Gene Symbols: Nxf1
|
|
Molecular weight:
70,300 Da
|
|
Basal Isoelectric point:
8.92
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
