NXF1 Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export. Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export. Belongs to the NXF family. Expressed ubiquitously. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA-binding
Chromosomal Location of Human Ortholog: 11q12.3
Cellular Component:  cytoplasm; cytosol; nuclear inclusion body; nuclear pore; nuclear speck; nucleoplasm; nucleus
Molecular Function:  mRNA binding; protein binding
Biological Process:  mRNA export from nucleus; RNA export from nucleus; viral process
Reference #:  Q9UBU9 (UniProtKB)
Alt. Names/Synonyms: DKFZp667O0311; MEX67; mRNA export factor TAP; Nuclear RNA export factor 1; NXF1; TAP; tip associating protein; Tip-associated protein; Tip-associating protein
Gene Symbols: NXF1
Molecular weight: 70,182 Da
Basal Isoelectric point: 8.74  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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