NEO1 Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response. Belongs to the immunoglobulin superfamily. DCC family. Widely expressed and also in cancer cell lines. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 9|9 B
Cellular Component:  cell surface; Golgi apparatus; integral component of membrane; integral component of plasma membrane; intracellular vesicle; membrane; neuronal cell body; nucleoplasm; plasma membrane; plasma membrane protein complex
Molecular Function:  BMP receptor binding; cadherin binding; co-receptor binding; protein binding; signaling receptor activity
Biological Process:  axon guidance; cell adhesion; iron ion homeostasis; myoblast fusion; negative regulation of axon regeneration; negative regulation of neuron death; negative regulation of protein secretion; nervous system development; neuron migration; positive regulation of BMP signaling pathway; regulation of axon regeneration; regulation of neuron migration; regulation of transcription, DNA-templated
Reference #:  P97798 (UniProtKB)
Alt. Names/Synonyms: 2610028H22Rik; AI327052; D930014N22Rik; Igdcc; Igdcc2; Neo1; Neogenin; Ngn
Gene Symbols: Neo1
Molecular weight: 163,160 Da
Basal Isoelectric point: 6.02  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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NEO1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene