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NEO1
Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response. Belongs to the immunoglobulin superfamily. DCC family. Widely expressed and also in cancer cell lines. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Receptor, misc. |
| Chromosomal Location of human Ortholog: 15q24.1 |
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Cellular Component:
axonal growth cone; cell surface; Golgi apparatus; intracellular vesicle; nucleoplasm; plasma membrane; plasma membrane protein complex
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Molecular Function:
BMP receptor binding; cadherin binding; co-receptor binding; protein binding; signaling receptor activity
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Biological Process:
axon guidance; cell adhesion; cell-cell adhesion; intracellular iron ion homeostasis; multicellular organismal-level iron ion homeostasis; myoblast fusion; negative regulation of axon regeneration; negative regulation of protein secretion; neuron migration; positive regulation of BMP signaling pathway; protein secretion; regulation of DNA-templated transcription
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Reference #:
Q92859
(UniProtKB)
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Alt. Names/Synonyms: DKFZp547A066; DKFZp547B146; IGDCC2; Immunoglobulin superfamily DCC subclass member 2; NEO1; Neogenin; neogenin 1; neogenin homolog 1; neogenin homolog 1 (chicken); NGN; NTN1R2
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Gene Symbols: NEO1
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Molecular weight:
160,017 Da
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Basal Isoelectric point:
6.08
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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