NEO1 Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response. Belongs to the immunoglobulin superfamily. DCC family. Widely expressed and also in cancer cell lines. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of human Ortholog: 15q24.1
Cellular Component:  Golgi apparatus; integral component of plasma membrane; nucleoplasm; plasma membrane; plasma membrane protein complex
Molecular Function:  co-receptor binding; protein binding; signaling receptor activity
Biological Process:  axon guidance; cell adhesion; iron ion homeostasis; positive regulation of BMP signaling pathway
Reference #:  Q92859 (UniProtKB)
Alt. Names/Synonyms: DKFZp547A066; DKFZp547B146; IGDCC2; Immunoglobulin superfamily DCC subclass member 2; NEO1; Neogenin; neogenin 1; neogenin homolog 1; neogenin homolog 1 (chicken); NGN; NTN1R2
Gene Symbols: NEO1
Molecular weight: 160,017 Da
Basal Isoelectric point: 6.08  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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NEO1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB