GGTL3 Cleaves glutathione conjugates. Belongs to the gamma-glutamyltransferase family. Widely expressed, but at low level, except in the airway epithelial cells. Detected in brain, heart, kidney, liver, lung, spleen, testis and trachea. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.3.2.2; EC 3.4.19.13; Lipid Metabolism - arachidonic acid; Membrane protein, integral; Other Amino Acids Metabolism - cyanoamino acid; Other Amino Acids Metabolism - glutathione; Other Amino Acids Metabolism - selenoamino acid; Other Amino Acids Metabolism - taurine and hypotaurine; Transferase
Chromosomal Location of Human Ortholog: 2|2 H1
Cellular Component:  integral component of membrane; membrane; plasma membrane
Molecular Function:  glutathione hydrolase activity; hydrolase activity; peptidyltransferase activity; transferase activity; transferase activity, transferring acyl groups
Biological Process:  glutathione biosynthetic process; glutathione catabolic process; negative regulation of response to oxidative stress
Reference #:  Q99JP7 (UniProtKB)
Alt. Names/Synonyms: 1110017C11Rik; 6330563L03Rik; Gamma-glutamyltransferase 7; Gamma-glutamyltransferase 7 heavy chain; Gamma-glutamyltransferase 7 light chain; Gamma-glutamyltransferase-like 3; Gamma-glutamyltranspeptidase 7; GGT 7; Ggt7; Ggtl3; Glutathione hydrolase 7; mFLJ00311 protein; MGC12004; OTTMUSP00000017178
Gene Symbols: Ggt7
Molecular weight: 70,251 Da
Basal Isoelectric point: 4.91  Predict pI for various phosphorylation states
Select Structure to View Below

GGTL3

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene