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GGTL3
Cleaves glutathione conjugates. Belongs to the gamma-glutamyltransferase family. Widely expressed, but at low level, except in the airway epithelial cells. Detected in brain, heart, kidney, liver, lung, spleen, testis and trachea. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.3.2.2; EC 3.4.19.13; Lipid Metabolism - arachidonic acid; Membrane protein, integral; Other Amino Acids Metabolism - cyanoamino acid; Other Amino Acids Metabolism - glutathione; Other Amino Acids Metabolism - selenoamino acid; Other Amino Acids Metabolism - taurine and hypotaurine; Transferase |
| Chromosomal Location of human Ortholog: 20q11.22 |
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Cellular Component:
plasma membrane
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Molecular Function:
glutathione hydrolase activity; hypoglycin A gamma-glutamyl transpeptidase activity; leukotriene C4 gamma-glutamyl transferase activity; protein binding
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Biological Process:
glutathione biosynthetic process; glutathione catabolic process; leukotriene D4 biosynthetic process; negative regulation of response to oxidative stress
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Reference #:
Q9UJ14
(UniProtKB)
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Alt. Names/Synonyms: D20S101; dJ18C9.2; gamma-glutamyltransferase 4; Gamma-glutamyltransferase 7; Gamma-glutamyltransferase 7 heavy chain; Gamma-glutamyltransferase 7 light chain; Gamma-glutamyltransferase-like 3; Gamma-glutamyltransferase-like 5; Gamma-glutamyltranspeptidase 7; gamma-glutamyltranspeptidase-like 3; GGT 7; GGT4; GGT7; GGTL3; GGTL5; Glutathione hydrolase 7; Glutathione hydrolase 7 heavy chain; Glutathione hydrolase 7 light chain
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Gene Symbols: GGT7
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Molecular weight:
70,467 Da
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Basal Isoelectric point:
4.96
Predict pI for various phosphorylation states
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