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MBIP
Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Ubiquitous. High expression seen in the heart and lung. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Protein kinase, regulatory subunit |
| Chromosomal Location of mouse Ortholog: 12|12 C1 |
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Cellular Component:
ATAC complex; cytoplasm; cytosol; mitotic spindle; nucleolus; nucleoplasm; nucleus
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Molecular Function:
identical protein binding; protein binding; protein kinase inhibitor activity
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Biological Process:
histone H3 acetylation; histone H3-K14 acetylation; positive regulation of gene expression; positive regulation of JNK cascade; regulation of cell cycle; regulation of cell division; regulation of DNA-templated transcription; regulation of embryonic development; regulation of histone deacetylation; regulation of transcription by RNA polymerase II; regulation of tubulin deacetylation
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Reference #:
Q99LQ1
(UniProtKB)
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Alt. Names/Synonyms: 4933408E06Rik; MAP3K12 binding inhibitory protein 1; MAP3K12-binding inhibitory protein 1; MAPK upstream kinase-binding inhibitory protein; Mbip; MBIP1; MGC7681; MUK-binding inhibitory protein
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Gene Symbols: Mbip
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Molecular weight:
38,333 Da
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Basal Isoelectric point:
6.68
Predict pI for various phosphorylation states
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