MBIP Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Ubiquitous. High expression seen in the heart and lung. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, regulatory subunit
Chromosomal Location of mouse Ortholog: 12|12 C1
Cellular Component:  Ada2/Gcn5/Ada3 transcription activator complex; cytoplasm; cytosol; nucleolus; nucleus
Molecular Function:  identical protein binding; molybdopterin synthase activity; protein binding
Biological Process:  histone H3 acetylation; molybdopterin cofactor biosynthetic process
Reference #:  Q99LQ1 (UniProtKB)
Alt. Names/Synonyms: 4933408E06Rik; MAP3K12 binding inhibitory protein 1; MAP3K12-binding inhibitory protein 1; MAPK upstream kinase-binding inhibitory protein; Mbip; MBIP1; MGC7681; MUK-binding inhibitory protein
Gene Symbols: Mbip
Molecular weight: 38,333 Da
Basal Isoelectric point: 6.68  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene