ABCB7 Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins. Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter; Transporter, ABC family
Chromosomal Location of mouse Ortholog: X D|X 46.58 cM
Cellular Component:  membrane; mitochondrial inner membrane; mitochondrion
Molecular Function:  ABC-type iron-sulfur cluster transporter activity; ABC-type transporter activity; ATP binding; ATP hydrolysis activity; ATPase-coupled transmembrane transporter activity; nucleotide binding; protein binding; protein homodimerization activity
Biological Process:  intracellular iron ion homeostasis; iron ion transmembrane transport; iron-sulfur cluster assembly; iron-sulfur cluster export from the mitochondrion; negative regulation of reactive oxygen species biosynthetic process; positive regulation of heme biosynthetic process; positive regulation of iron-sulfur cluster assembly; transmembrane transport
Reference #:  Q61102 (UniProtKB)
Alt. Names/Synonyms: AA517758; Abc; ABC transporter 7 protein; Abc7; Abcb7; ATP-binding cassette 7; ATP-binding cassette sub-family B member 7, mitochondrial; ATP-binding cassette transporter 7; ATP-binding cassette, sub-family B (MDR/TAP), member 7; AU019072; Iron-sulfur clusters transporter ABCB7, mitochondrial
Gene Symbols: Abcb7
Molecular weight: 82,581 Da
Basal Isoelectric point: 9.36  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein