CTNNA3
May be involved in formation of stretch-resistant cell-cell adhesion complexes. Belongs to the vinculin/alpha-catenin family. Predominantly expressed in heart and testis. Expressed at lower levels in brain, kidney, liver and skeletal muscle. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Cell adhesion |
Chromosomal Location of human Ortholog: 10q21.3 |
Cellular Component:
adherens junction; cytoplasm; cytoskeleton; desmosome; fascia adherens; lamellipodium
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Molecular Function:
actin filament binding; beta-catenin binding; cadherin binding; protein binding
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Biological Process:
bundle of His cell-Purkinje myocyte adhesion involved in cell communication; cell migration; cell-cell adhesion; regulation of heart rate by cardiac conduction; regulation of ventricular cardiac muscle cell action potential
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Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 13
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Reference #:
Q9UI47
(UniProtKB)
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Alt. Names/Synonyms: Alpha T-catenin; alpha-catenin-like protein; alpha-T-catenin; ARVD13; Cadherin-associated protein; catenin (cadherin-associated protein), alpha 3; catenin alpha 3; Catenin alpha-3; CTNA3; CTNNA3; MGC26194; MGC75041; VR22
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Gene Symbols: CTNNA3
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Molecular weight:
99,809 Da
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Basal Isoelectric point:
5.83
Predict pI for various phosphorylation states
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CST Pathways:
Wnt/ß-Catenin Signaling
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