CTNNA3 May be involved in formation of stretch-resistant cell-cell adhesion complexes. Belongs to the vinculin/alpha-catenin family. Predominantly expressed in heart and testis. Expressed at lower levels in brain, kidney, liver and skeletal muscle. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion
Chromosomal Location of human Ortholog: 10q21.3
Cellular Component:  adherens junction; cytoplasm; cytoskeleton; desmosome; fascia adherens; lamellipodium
Molecular Function:  actin filament binding; beta-catenin binding; cadherin binding; protein binding
Biological Process:  bundle of His cell-Purkinje myocyte adhesion involved in cell communication; cell migration; cell-cell adhesion; regulation of heart rate by cardiac conduction; regulation of ventricular cardiac muscle cell action potential
Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 13
Reference #:  Q9UI47 (UniProtKB)
Alt. Names/Synonyms: Alpha T-catenin; alpha-catenin-like protein; alpha-T-catenin; ARVD13; Cadherin-associated protein; catenin (cadherin-associated protein), alpha 3; catenin alpha 3; Catenin alpha-3; CTNA3; CTNNA3; MGC26194; MGC75041; VR22
Gene Symbols: CTNNA3
Molecular weight: 99,809 Da
Basal Isoelectric point: 5.83  Predict pI for various phosphorylation states
CST Pathways:  Wnt/ß-Catenin Signaling
Select Structure to View Below

CTNNA3

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein