ARHGAP18 Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state. Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1. Regulates cell shape, spreading, and migration. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, Rac/Rho
Chromosomal Location of human Ortholog: 6q22.33
Cellular Component:  cytoplasm; cytosol; nuclear speck; plasma membrane
Molecular Function:  GTPase activator activity
Biological Process:  positive regulation of GTPase activity; regulation of actin cytoskeleton organization; regulation of actin filament polymerization; regulation of cell motility; regulation of cell shape; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction
Reference #:  Q8N392 (UniProtKB)
Alt. Names/Synonyms: ARHGAP18; bA307O14.2; FLJ25728; MacGAP; MGC126757; MGC138145; RHG18; Rho GTPase activating protein 18; Rho GTPase-activating protein 18; Rho-type GTPase-activating protein 18; SENEX
Gene Symbols: ARHGAP18
Molecular weight: 74,977 Da
Basal Isoelectric point: 6.1  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene