FIGNL1 Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation. May play a role in the control of male meiosis dynamic. Belongs to the AAA ATPase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.4.-; Hydrolase
Chromosomal Location of Human Ortholog: 7p12.2
Cellular Component:  cytoplasm; nuclear chromosome; nucleus; perinuclear region of cytoplasm
Molecular Function:  ATP binding; hydrolase activity; magnesium ion binding; protein binding
Biological Process:  ATP metabolic process; cellular response to ionizing radiation; male meiotic nuclear division; microtubule severing; negative regulation of apoptotic process; negative regulation of intrinsic apoptotic signaling pathway; osteoblast differentiation; osteoblast proliferation; regulation of cell cycle; regulation of double-strand break repair via homologous recombination
Reference #:  Q6PIW4 (UniProtKB)
Alt. Names/Synonyms: fidgetin like 1; fidgetin-like 1; Fidgetin-like protein 1; FIGL1; FIGNL1
Gene Symbols: FIGNL1
Molecular weight: 74,077 Da
Basal Isoelectric point: 8.07  Predict pI for various phosphorylation states
Select Structure to View Below

FIGNL1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein