JADE2 Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Acts as a E3 ubiquitin-protein ligase mediating the ubiquitination and subsequent proteasomal degradation of target protein histone demethylase KDM1A. Also acts as a ubiquitin ligase E3 toward itself. Positive regulator of neurogenesis. Belongs to the JADE family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 5q31.1
Cellular Component:  histone acetyltransferase complex; nucleoplasm
Molecular Function:  metal ion binding; protein binding; transferase activity
Biological Process:  histone H3 acetylation; histone H4-K12 acetylation; histone H4-K5 acetylation; histone H4-K8 acetylation; protein ubiquitination
Reference #:  Q9NQC1 (UniProtKB)
Alt. Names/Synonyms: E3 ubiquitin-protein ligase Jade-2; jade family PHD finger 2; Jade family PHD finger protein 2; JADE-2; JADE2; KIAA0239; PHD finger protein 15; PHF15; Protein Jade-2
Gene Symbols: JADE2
Molecular weight: 87,466 Da
Basal Isoelectric point: 5.15  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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