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H2B2F
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Belongs to the histone H2B family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding |
| Chromosomal Location of human Ortholog: 1q21.2 |
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Cellular Component:
cytosol; nucleoplasm; nucleosome
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Molecular Function:
DNA binding; protein heterodimerization activity; structural constituent of chromatin
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Reference #:
Q5QNW6
(UniProtKB)
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Alt. Names/Synonyms: FLJ35099; FLJ56780; FLJ56787; H2B clustered histone 18; H2B-clustered histone 18; H2B2F; H2BC18; HIST2H2BF; histone 2, H2bf; histone cluster 2 H2B family member f; histone cluster 2, H2bf; Histone H2B type 2-F; MGC131639
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Gene Symbols: H2BC18
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Molecular weight:
13,789 Da
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Basal Isoelectric point:
10.32
Predict pI for various phosphorylation states
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