|
ASCC3
3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation. Belongs to the helicase family. Ubiquitous. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: EC 3.6.4.12; Helicase; Transcription, coactivator/corepressor |
| Chromosomal Location of human Ortholog: 6q16.3 |
|
Cellular Component:
activating signal cointegrator 1 complex; cytosol; cytosolic ribosome; DNA repair complex; nuclear speck; nucleoplasm; nucleus
|
|
Molecular Function:
3'-5' DNA helicase activity; ATP binding; ATP hydrolysis activity; protein binding
|
|
Biological Process:
cell population proliferation; DNA dealkylation involved in DNA repair; DNA duplex unwinding; rescue of stalled ribosome; ribosome disassembly; ribosome-associated ubiquitin-dependent protein catabolic process
|
|
Disease: Intellectual Developmental Disorder, Autosomal Recessive 81
|
|
Reference #:
Q8N3C0
(UniProtKB)
|
|
Alt. Names/Synonyms: Activating signal cointegrator 1 complex subunit 3; ASC-1 complex subunit p200; ASC1p200; ASCC3; B630009I04Rik; dJ121G13.4; DJ467N11.1; HELC1; HELIC1; Helicase, ATP binding 1; MGC26074; RNA helicase family; RNAH; Trip4 complex subunit p200
|
|
Gene Symbols: ASCC3
|
|
Molecular weight:
251,460 Da
|
|
Basal Isoelectric point:
6.64
Predict pI for various phosphorylation states
|
