IP3R2 Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA. Belongs to the InsP3 receptor family. Isoform Short is found in skeletal muscle and heart. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 12p11.23
Cellular Component:  cell cortex; endoplasmic reticulum; endoplasmic reticulum membrane; integral component of membrane; nucleus; plasma membrane; platelet dense tubular network membrane; receptor complex; sarcoplasmic reticulum membrane
Molecular Function:  calcium ion transmembrane transporter activity; inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; scaffold protein binding
Biological Process:  cellular response to cAMP; cellular response to ethanol; inositol phosphate-mediated signaling; platelet activation; regulation of cardiac conduction; regulation of insulin secretion; release of sequestered calcium ion into cytosol; response to hypoxia; signal transduction
Disease: Anhidrosis, Isolated, With Normal Sweat Glands
Reference #:  Q14571 (UniProtKB)
Alt. Names/Synonyms: ANHD; CFAP48; cilia and flagella associated protein 48; inositol 1,4,5-triphosphate receptor, type 2; Inositol 1,4,5-trisphosphate receptor type 2; InsP3R2; IP3 receptor; IP3 receptor isoform 2; IP3R 2; IP3R2; ITPR2; Type 2 inositol 1,4,5-trisphosphate receptor; Type 2 InsP3 receptor
Gene Symbols: ITPR2
Molecular weight: 308,064 Da
Basal Isoelectric point: 6.01  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene