Bcl-2 Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release. Belongs to the Bcl-2 family. Expressed in a variety of tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Autophagy; Membrane protein, integral; Oncoprotein
Chromosomal Location of Human Ortholog: 18q21.33
Cellular Component:  cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; membrane; mitochondrial outer membrane; mitochondrion; myelin sheath; nuclear membrane; nucleoplasm; nucleus; pore complex; protein-containing complex
Molecular Function:  BH3 domain binding; channel activity; channel inhibitor activity; identical protein binding; protease binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein phosphatase 2A binding; sequence-specific DNA binding; transcription factor binding; ubiquitin protein ligase binding
Biological Process:  actin filament organization; apoptotic process; axon regeneration; axonogenesis; B cell homeostasis; B cell lineage commitment; B cell proliferation; B cell receptor signaling pathway; behavioral fear response; branching involved in ureteric bud morphogenesis; CD8-positive, alpha-beta T cell lineage commitment; cell aging; cell-cell adhesion; cellular response to DNA damage stimulus; cellular response to glucose starvation; cellular response to hypoxia; cochlear nucleus development; cytokine-mediated signaling pathway; defense response to virus; digestive tract morphogenesis; ear development; endoplasmic reticulum calcium ion homeostasis; extrinsic apoptotic signaling pathway via death domain receptors; female pregnancy; focal adhesion assembly; gland morphogenesis; glomerulus development; hair follicle morphogenesis; homeostasis of number of cells within a tissue; humoral immune response; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; intrinsic apoptotic signaling pathway in response to oxidative stress; lymphoid progenitor cell differentiation; male gonad development; melanin metabolic process; melanocyte differentiation; mesenchymal cell development; metanephros development; negative regulation of anoikis; negative regulation of apoptotic process; negative regulation of apoptotic signaling pathway; negative regulation of autophagy; negative regulation of calcium ion transport into cytosol; negative regulation of cell growth; negative regulation of cell migration; negative regulation of cellular pH reduction; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of mitochondrial depolarization; negative regulation of myeloid cell apoptotic process; negative regulation of neuron apoptotic process; negative regulation of ossification; negative regulation of osteoblast proliferation; negative regulation of reactive oxygen species metabolic process; negative regulation of retinal cell programmed cell death; neuron apoptotic process; oocyte development; organ growth; ossification; ovarian follicle development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; pigment granule organization; positive regulation of B cell proliferation; positive regulation of catalytic activity; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of melanocyte differentiation; positive regulation of multicellular organism growth; positive regulation of neuron maturation; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; positive regulation of skeletal muscle fiber development; positive regulation of smooth muscle cell migration; post-embryonic development; protein dephosphorylation; protein polyubiquitination; reactive oxygen species metabolic process; regulation of calcium ion transport; regulation of cell-matrix adhesion; regulation of gene expression; regulation of glycoprotein biosynthetic process; regulation of mitochondrial membrane permeability; regulation of mitochondrial membrane potential; regulation of nitrogen utilization; regulation of protein heterodimerization activity; regulation of protein homodimerization activity; regulation of protein stability; regulation of transmembrane transporter activity; regulation of viral genome replication; release of cytochrome c from mitochondria; renal system process; response to cytokine; response to drug; response to gamma radiation; response to glucocorticoid; response to hydrogen peroxide; response to iron ion; response to ischemia; response to nicotine; response to radiation; response to toxic substance; response to UV-B; spleen development; T cell differentiation in thymus; T cell homeostasis; thymus development; transmembrane transport
Reference #:  P10415 (UniProtKB)
Alt. Names/Synonyms: Apoptosis regulator Bcl-2; B-cell CLL/lymphoma 2; Bcl-2; BCL2
Gene Symbols: BCL2
Molecular weight: 26,266 Da
Basal Isoelectric point: 6.75  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Autophagy Signaling  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB