ARHGEF11 May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1q23.1
Cellular Component:  cytoplasm; cytosol; membrane
Molecular Function:  G-protein coupled receptor binding; GTPase activator activity; guanyl-nucleotide exchange factor activity; protein binding; Rho guanyl-nucleotide exchange factor activity
Biological Process:  actin cytoskeleton organization; establishment of cell polarity; G-protein coupled receptor signaling pathway; positive regulation of apoptosis; positive regulation of GTPase activity; positive regulation of transcription, DNA-templated; regulation of cell growth; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; Rho protein signal transduction; striated muscle contraction
Reference #:  O15085 (UniProtKB)
Alt. Names/Synonyms: ARHGB; ARHGEF11; DKFZp667F1223; glutamate transporter EAAT4-associated protein 48; GTRAP48; KIAA0380; PDZ-RhoGEF; Rho guanine exchange factor (GEF) 11; Rho guanine nucleotide exchange factor (GEF) 11; Rho guanine nucleotide exchange factor 11; RhoA-specific guanine nucleotide exchange factor; RhoGEF glutamate transport modulator
Gene Symbols: ARHGEF11
Molecular weight: 167,704 Da
Basal Isoelectric point: 5.33  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Microtubule Dynamics
Select Structure to View Below

ARHGEF11

Protein Structure Not Found.


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