H1D Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation. Belongs to the histone H1/H5 family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of mouse Ortholog: 13|13 A3.1
Cellular Component:  chromosome; nuclear chromatin; nuclear euchromatin; nucleosome; nucleus
Molecular Function:  chromatin DNA binding; DNA binding; double-stranded DNA binding; nucleosomal DNA binding; protein binding
Biological Process:  chromosome condensation; histone H3-K27 trimethylation; histone H3-K4 trimethylation; negative regulation of chromatin silencing; negative regulation of DNA recombination; negative regulation of transcription by RNA polymerase II; nucleosome assembly; nucleosome positioning; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated
Reference #:  P43277 (UniProtKB)
Alt. Names/Synonyms: H1 histone family, member 3; H1 VAR.4; H1-3; H1.3; H1.3 linker histone, cluster member; H13; H1d; H1f3; H1s-; H1s-4; Hist1h; Hist1h1d; histone 1, family 3; histone 1, H1d; histone cluster 1, H1d; Histone H1.3; OTTMUSP00000000521
Gene Symbols: H1f3
Molecular weight: 22,100 Da
Basal Isoelectric point: 11.03  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene