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BAD
Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2. Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. Belongs to the Bcl-2 family. Expressed in a wide variety of tissues. Note: This description may include information from UniProtKB.
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| Protein type: Apoptosis |
| Chromosomal Location of mouse Ortholog: 19|19 A |
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Cellular Component:
BAD-BCL-2 complex; cytoplasm; cytosol; membrane; mitochondrial outer membrane; mitochondrion
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Molecular Function:
14-3-3 protein binding; cysteine-type endopeptidase activator activity involved in apoptotic process; lipid binding; phospholipid binding; protein binding; protein kinase B binding; protein kinase binding; protein phosphatase 2B binding; protein phosphatase binding
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Biological Process:
activation of cysteine-type endopeptidase activity; activation of cysteine-type endopeptidase activity involved in apoptotic process; ADP metabolic process; apoptotic process; apoptotic signaling pathway; ATP metabolic process; cellular response to hypoxia; cellular response to lipid; cellular response to nicotine; cellular response to organic substance; cytokine-mediated signaling pathway; epithelial cell proliferation; extrinsic apoptotic signaling pathway; extrinsic apoptotic signaling pathway in absence of ligand; extrinsic apoptotic signaling pathway via death domain receptors; glucose catabolic process; glucose homeostasis; induction by virus of host apoptotic process; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway in response to DNA damage; pore complex assembly; positive regulation of apoptotic process; positive regulation of B cell differentiation; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of epithelial cell proliferation; positive regulation of glucokinase activity; positive regulation of granulosa cell apoptotic process; positive regulation of insulin secretion; positive regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress; positive regulation of mitochondrial membrane potential; positive regulation of proteolysis; positive regulation of release of cytochrome c from mitochondria; positive regulation of T cell differentiation; positive regulation of type B pancreatic cell development; regulation of apoptotic process; regulation of cysteine-type endopeptidase activity involved in apoptotic process; regulation of mitochondrial membrane permeability; release of cytochrome c from mitochondria; suppression by virus of host apoptotic process; type B pancreatic cell proliferation
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Reference #:
Q61337
(UniProtKB)
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Alt. Names/Synonyms: AI325008; BAD; Bbc2; Bbc6; Bcl-2-binding component 6; Bcl-associated death promoter; Bcl-xL/Bcl-2-associated death promoter; Bcl2 antagonist of cell death; Bcl2-associated agonist of cell death; OTTMUSP00000017561
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Gene Symbols: Bad
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Molecular weight:
22,080 Da
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Basal Isoelectric point:
9.15
Predict pI for various phosphorylation states
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CST Pathways:
Apoptosis Regulation
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ErbB/HER Signaling
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Growth And Differentiation Control by MAPKs
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Inhibition of Apoptosis
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Insulin Receptor Signaling
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Mitochondrial Control of Apoptosis
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PI3K/Akt Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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