IRX5 Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and control specific aspects of visual function in circuits of the mammalian retina. Could be involved in the regulation of both the cell cycle and apoptosis in prostate cancer cells. Involved in craniofacial and gonadal development. Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing CXCL12. Belongs to the TALE/IRO homeobox family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of human Ortholog: 16q12.2
Cellular Component:  chromatin; nucleus
Molecular Function:  DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding; vitamin D binding
Biological Process:  cell development; embryonic cranial skeleton morphogenesis; gonad development; neuron differentiation; regulation of transcription by RNA polymerase II; response to stimulus; visual perception
Disease: Hamamy Syndrome
Reference #:  P78411 (UniProtKB)
Alt. Names/Synonyms: HMMS; Homeodomain protein IRX-2A; Homeodomain protein IRXB2; iroquois homeobox 5; Iroquois homeobox protein 5; Iroquois-class homeodomain protein IRX-5; IRX-2a; IRX2A; IRX5; IRXB2
Gene Symbols: IRX5
Molecular weight: 50,361 Da
Basal Isoelectric point: 6.03  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene