UCHL5 Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1. Belongs to the peptidase C12 family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease
Chromosomal Location of Human Ortholog: 1 F|1 62.54 cM
Cellular Component:  cytoplasm; cytosol; cytosolic proteasome complex; Ino80 complex; mitochondrion; nucleoplasm; nucleus; proteasome complex
Molecular Function:  cysteine-type peptidase activity; endopeptidase inhibitor activity; hydrolase activity; peptidase activity; proteasome binding; thiol-dependent ubiquitin-specific protease activity; thiol-dependent ubiquitinyl hydrolase activity
Biological Process:  cellular response to DNA damage stimulus; DNA recombination; DNA repair; forebrain morphogenesis; lateral ventricle development; midbrain development; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination; regulation of proteasomal protein catabolic process; ubiquitin-dependent protein catabolic process
Reference #:  Q9WUP7 (UniProtKB)
Alt. Names/Synonyms: 5830413B11Rik; ubiquitin C-terminal hydrolase 37; Ubiquitin C-terminal hydrolase UCH37; ubiquitin carboxyl-terminal esterase L5; Ubiquitin carboxyl-terminal hydrolase isozyme L5; Ubiquitin thioesterase L5; UCH-L5; Uch37; Uchl5
Gene Symbols: Uchl5
Molecular weight: 37,617 Da
Basal Isoelectric point: 5.24  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene