UCHL5 Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1. Belongs to the peptidase C12 family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease
Chromosomal Location of human Ortholog: 1q31.2
Cellular Component:  cytosol; Ino80 complex; mitochondrion; nucleoplasm; nucleus; proteasome complex
Molecular Function:  endopeptidase inhibitor activity; proteasome binding; protein binding; thiol-dependent ubiquitin-specific protease activity
Biological Process:  DNA recombination; DNA repair; negative regulation of endopeptidase activity; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination; regulation of proteasomal protein catabolic process; ubiquitin-dependent protein catabolic process
Reference #:  Q9Y5K5 (UniProtKB)
Alt. Names/Synonyms: CGI-70; INO80 complex subunit R; INO80R; ubiquitin C-terminal hydrolase L5; Ubiquitin C-terminal hydrolase UCH37; ubiquitin carboxyl-terminal esterase L5; Ubiquitin carboxyl-terminal hydrolase isozyme L5; ubiquitin carboxyl-terminal hydrolase L5; Ubiquitin thioesterase L5; UCH-L5; UCH37; UCHL5
Gene Symbols: UCHL5
Molecular weight: 37,607 Da
Basal Isoelectric point: 5.23  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein