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UCHL5
Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1. Belongs to the peptidase C12 family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease |
| Chromosomal Location of human Ortholog: 1q31.2 |
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Cellular Component:
cytosol; Ino80 complex; mitochondrion; nucleoplasm; nucleus; proteasome complex
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Molecular Function:
endopeptidase inhibitor activity; proteasome binding; protein binding; thiol-dependent ubiquitin-specific protease activity
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Biological Process:
DNA recombination; DNA repair; negative regulation of endopeptidase activity; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination; regulation of proteasomal protein catabolic process; ubiquitin-dependent protein catabolic process
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Reference #:
Q9Y5K5
(UniProtKB)
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Alt. Names/Synonyms: CGI-70; INO80 complex subunit R; INO80R; ubiquitin C-terminal hydrolase L5; Ubiquitin C-terminal hydrolase UCH37; ubiquitin carboxyl-terminal esterase L5; Ubiquitin carboxyl-terminal hydrolase isozyme L5; ubiquitin carboxyl-terminal hydrolase L5; Ubiquitin thioesterase L5; UCH-L5; UCH37; UCHL5
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Gene Symbols: UCHL5
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Molecular weight:
37,607 Da
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Basal Isoelectric point:
5.23
Predict pI for various phosphorylation states
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